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국회도서관 홈으로 정보검색 소장정보 검색

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Purpose: Beta-tricalcium phosphate (β-TCP) is a synthetic calcium phosphate ceramic that has widely been used as a bone

material to repair bone defects. Despite many clinical studies, the molecular mechanism whereby this biomaterial alters the

gene expression in osteoblasts to promote bone formation is poorly understood. Thus, we attempted to address this question

by using microarray techniques to identify the genes that are differentially regulated in osteoblasts exposed to β-TCP.

Methods: By using DNA microarrays, we identified several genes whose expression levels were significantly up- or down-regulated

in osteoblast-likeMG-63cells cultured with β-TCP at a concentration of 100 mg/10 ml for 24 hours.

Results: The differentially expressed genes covered a broad range of functional activities: signal transduction, transcription,

cell cycle regulation, vesicular transport, apoptosis, immunity, cytoskeletal elements and cell proliferation and differentiation.

Conclusion: The gene expression changes related to cell proliferation and differentiation, vesicle transport, immunity and

defense could affect the osteogenic activities of osteoblasts for bone regeneration. However, further studies will be required

to verify the relative importance of these genes in bone formation, their temporal and spatial expression patterns and their

interactions with each other.

권호기사

권호기사 목록 테이블로 기사명, 저자명, 페이지, 원문, 기사목차 순으로 되어있습니다.
기사명 저자명 페이지 원문 목차
다공성 폴리에틸렌을 이용한 하악골 함몰의 교정 : 증례보고 임재형, 김수관, 문성용, 오지수, 박진주, 정미애 pp.363-367

실크 피브로인 지지체와 Substance P를 이용한 골 이식재 박기유, 최교희, 박영주, 송지영, 김성곤, 조유영, 권해용, 강석우 pp.293-300

Alterations of Gene Expression by Beta-tricalcium Phosphate in Osteoblast-like MG63 Cells Jae-Yun Jeon, Tae-Yun Im, Seung-Hwan Jeon, Kyung-Gyun Hwang, Chang-Joo Park pp.308-313

구개열 환자의 치조열 골이식의 평가 노량석, 김종배, 진병로, 권대근, 이상한 pp.314-318

하악상행지 시상분할골절단술 시 하악후퇴량의 방사선학적 예측 노량석, 김진욱, 권대근, 이상한 pp.323-330

악안면 기형의 상하악골 전후방적 위치관계에 대한 McNamara Analysis와 Delaire Analysis의 기준선 비교연구 정승원, 김소미, 변성수, 박형식, 정영수 pp.331-336

악하부에 발생한 Progressive Transformation of Germinal Centers : 증례보고 박수원, 장수미, 김동율, 손장호, 조영철, 성일용 pp.368-372

하악 관절와의 형태가 하악 이부편위에 미치는 영향에 관한 3차원 영상 연구 조진형, 이경민, 박홍주, 황현식 pp.337-345

골유도재생술 시 비탈회 동종골와 우심막유래 차단막의 임상적 활용 임형섭, 김수관, 문성용, 오지수, 정경인, 박진주, 정미애 pp.359-362

Sandblasted, Large-grit and Acid-etched Implant에 대한 후향적 임상 연구 조지호, 김수관, 문성용, 오지수, 박진주, 정종원, 윤대웅, 양성수, 정미애 pp.352-358

골격성 3급 부정교합 환자에서 양측 상행지 시상분할 골절단술을 이용한 하악 후방이동 시 이동량에 따른 회귀현상 유경환, 김수관, 문성용, 오지수, 김생곤, 박진주, 정종원, 윤대웅, 양성수 pp.319-322

Response of Odontoblast to the Bio-Calcium Phosphate Cement Jin-Woo Kim, Sung-Won Kim, Gyoo-Cheon Kim, Yong-Deok Kim, Cheol-Hun Kim, Bok-Joo Kim, Uk-Kyu Kim pp.301-307

Cone-beam CT영상으로부터 얻어진 정모두부방사선사진에서 수평기준선의 설정 강희제, 김종렬, 김용일 pp.346-351

참고문헌 (25건) : 자료제공( 네이버학술정보 )

참고문헌 목록에 대한 테이블로 번호, 참고문헌, 국회도서관 소장유무로 구성되어 있습니다.
번호 참고문헌 국회도서관 소장유무
1 Histologic effect of pure-phase beta-tricalcium phosphate on bone regeneration in human artificial jawbone defects. 네이버 미소장
2 beta-Tricalcium phosphate promotes cell proliferation, osteogenesis and bone regeneration in intrabony defects in dogs. 네이버 미소장
3 The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue. 네이버 미소장
4 Buser D, Hoffmann B, Bernard JP, Lussi A, Mettler D, Schenk RK. Evaluation of filling materials in membrane-- protected bone defects. A comparative histomorphometric study in the mandible of miniature pigs. Clin Oral Implants Res 1998;9:137-50. 미소장
5 Jensen SS, Broggini N, HjØrting-Hansen E, Schenk R, Buser D. Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. A histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res 2006;17:237-43. 미소장
6 Ectopic osteogenesis with biphasic ceramics of hydroxyapatite and tricalcium phosphate in rabbits 네이버 미소장
7 Intraindividual comparative animal study of alpha- and beta-tricalcium phosphate degradation in conjunction with simultaneous insertion of dental implants. 네이버 미소장
8 Genetic effects of anorganic bovine bone (Bio-Oss) on osteoblast-like MG63 cells. 네이버 미소장
9 Genetic expression profiling of six odontogenic tumors. 네이버 미소장
10 Zirconium oxide: analysis of MG63 osteoblast-like cell response by means of a microarray technology 네이버 미소장
11 Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage. 네이버 미소장
12 Interaction of selenium compounds with zinc finger proteins involved in DNA repair. 네이버 미소장
13 Role of CLASP2 in Microtubule Stabilization and the Regulation of Persistent Motility 네이버 미소장
14 IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress. 네이버 미소장
15 West RR, Tenbarge KM, Olmsted JB. A model for microtubule- associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences. J Biol Chem 1999;266:21886-96. 미소장
16 JNK Activity Is Essential for Atf4 Expression and Late-Stage Osteoblast Differentiation 네이버 미소장
17 Enhanced Osteoclastogenesis Causes Osteopenia in Twisted Gastrulation-Deficient Mice Through Increased BMP Signaling 네이버 미소장
18 Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2. 네이버 미소장
19 MPV17-associated hepatocerebral mitochondrial DNA depletion syndrome: New patients and novel mutations 네이버 미소장
20 The IRF family transcription factors in immunity and oncogenesis. 네이버 미소장
21 2′,5′-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro 네이버 미소장
22 Hong L, Chen Z, Zhang X, et al. Zinc ribbon domain containing 1 protein: modulator of multidrug resistance, tumorigenesis and cell cycle. Exp Oncol 2006;28:258-62. 미소장
23 Induction of the mammalian GRP78/BiP gene by Ca2+ depletion and formation of aberrant proteins: activation of the conserved stress-inducible grp core promoter element by the human nuclear factor YY1. 네이버 미소장
24 The limited difference between keratin patterns of squamous cell carcinomas and adenocarcinomas is explicable by both cell lineage and state of differentiation of tumour cells. 네이버 미소장
25 Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. 네이버 미소장