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Spergularia marina Griseb. (SM) is a halophyte that grows in mud flats. The aerial portions of SM have been eaten as vegetables and traditionally used to prevent chronic diseases in Korea. However, there has been no scientific report that demonstrates the pharmacological effects of SM. Glucagon-like peptide-1 (GLP-1) is important for the maintenance of glucose and energy homeostasis through acting as a signal in peripheral and neural systems. To discover a functional food for regulating glucose and energy homeostasis, we evaluated the effect of an aqueous ethanolic extract (AEE) of SM on GLP-1 release from enteroendocrine NCI-H716 cells. In addition, we explored the Takeda G-protein-coupled receptor 5 (TGR5) agonist activity of AEE-SM in Chinese hamster ovary (CHO)-K1 cells transiently transfected with human TGR5. As a result, treatment of NCI-H716 cells with AEE-SM increased GLP-1 secretion and intracellular Ca2 + and cyclic AMP (cAMP) levels in a dose-dependent manner. Transfection of NCI-H716 cells with TGR5-specific small interference RNA inhibited AEE-SMinduced GLP-1 secretion and the increase in Ca2 + and cAMP levels. Moreover, AEE-SM showed that the TGR5 agonist activity in CHO-K1 cells transiently transfected with TGR5. The results suggest that AEE-SM might be a candidate for a functional food to regulate glucose and energy homeostasis.

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기사명 저자명 페이지 원문 목차
Spergularia marina Induces Glucagon-Like Peptide-1 Secretion in NCI-H716 Cells Through Bile Acid Receptor Activation Kyong Kim, Yu Mi Lee, Mee-Ra Rhyu, Hye Young Kim pp.1197-1203
The Effect of Iron and Fat in a Diet Containing Green Tea Extract (Camellia sinensis) on the Antioxidant Capacity of Some Organs and the mRNA Expression of Specific Genes in Mice Antonios E. Koutelidakis, Dimosthenis Kizis, Konstantina Argyri, Alkistis Kyriakou, Michael Komaitis, Maria Kapsokefalou pp.1232-1238
Agave Fructans : Their Effect on Mineral Absorption and Bone Mineral Content María Isabel García-Vieyra, Alicia Del Real, Mercedes G. López pp.1247-1255
Long-Term(5 Years), High Daily Dosage of Dietary Agmatine-Evidence of Safety : A Case Report Gad M. Gilad, Varda H. Gilad pp.1256-1259
Specific Oligopeptides in Fermented Soybean Extract Inhibit NF-κB-Dependent iNOS and Cytokine Induction by Toll-Like Receptor Ligands Woo Hyung Lee, Hong Min Wu, Chan Gyu Lee, Dae Il Sung, Hye Jung Song, Toshiro Matsui, Han Bok Kim, Sang Geon Kim pp.1239-1246
Selection and Characterization of Cheonggukjang (Fast Fermented Soybean Paste)-Originated Bacterial Strains with a High Level of S-adenosyl-L-methionine Production and Probiotics Efficacy Sunhyun Park, Min-Jeong Kim, Jiyoung Hong, Hyo-Jin Kim, Sung-Hun Yi, Myung-Ki Lee pp.1170-1176
Enhancement of Broccoli Indole Glucosinolates by Methyl Jasmonate Treatment and Effects on Prostate Carcinogenesis Ann G. Liu, John A. Juvik, Elizabeth H. Jeffery, Lisa D. Berman-Booty, Steven K. Clinton, John W. Erdman, Jr pp.1177-1182
The Clinical Effects of Synsepalum dulcificum: A Review Kaki B. Swamy, Suwaibah Abd Hadi, Muniandy Sekaran, Mallikarjuna Rao Pichika pp.1165-1169
Functional and Metabolic Disorders in Celiac Disease : New Implications for Nutritional Treatment Sara FarnettiMaria Assunta Zocco, Matteo Garcovich, Antonio GasbarriniEsmeralda Capristo pp.1159-1164
Consumption of Dried Apple Peel Powder Increases Joint Function and Range of Motion Gitte S. Jensen, Victoria L. Attridge, Kathleen F. Benson, Joni L. Beaman, Steve G. Carter, David Ager pp.1204-1213
Effects of Jamaican Bitter Yam (Dioscorea polygonoides) and Diosgenin on Blood and Fecal Cholesterol in Rats Marsha-Lyn McKoy, Peta-Gaye Thomas, Helen Asemota, Felix Omoruyi, Oswald Simon pp.1183-1188
Lithospermum erythrorhizon Extract Protects Keratinocytes and Fibroblasts Against Oxidative Stress Hee Geun Yoo, Bong Han Lee, Wooki Kim, Jong Suk Lee, Gun Hee Kim, Ock K. Chun, Sung I. Koo, Dae-Ok Kim pp.1189-1196
Ligularia fischeri Extract Protects Against Oxidative-Stress-Induced Neurotoxicity in Mice and PC12 Cells Soo Jung Choi, Jae Kyeom Kim, Soo Hwan Suh, Cho Rong Kim, Hye Kyung Kim, Chang-Ju Kim, Gwi Gun Park, Cheung-Seog Park, Dong-Hoon Shin pp.1222-1231
Effects of Chicory Inulin on Serum Metabolites of Uric Acid, Lipids, Glucose, and Abdominal Fat Deposition in Quails Induced by Purine-Rich Diets Zhijian Lin, Bing Zhang, Xiaoqing Liu, Rui Jin, Wenjing Zhu pp.1214-1221

참고문헌 (17건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra 네이버 미소장
2 Hartman RL, Rabeler RK, Spergularia. In, Flora of North America, Vol. 5. (Flora of North America Editorial Committee, ed.). Oxford University Press, New York, 2005, pp. 16–23. 미소장
3 Chronic diuretic effect of the water extract of Spergularia purpurea in normal rats 네이버 미소장
4 Cholesterol-lowering activity of the aqueous extract of Spergularia purpurea in normal and recent-onset diabetic rats 네이버 미소장
5 Hypoglycaemic effect of Spergularia purpurea in normal and streptozotocin-induced diabetic rats 네이버 미소장
6 Eddouks M, Jouad H, Maghrani M, Lemhadri A, Burcelin R:Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice. Phytomed 2003; 10:594–599. 미소장
7 Effects of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats 네이버 미소장
8 Heo BG, Park Yj, Park YS, et al., Distribution status, physicochemical composition, and physiological activity of Spergularia marina cultivated. Korean J Community Liv Sci 2009; 20:181–191. 1202 KIM ET AL. 미소장
9 Glucose Sensing in L Cells: A Primary Cell Study 네이버 미소장
10 TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis 네이버 미소장
11 G-Protein-Coupled Receptors in Intestinal Chemosensation 네이버 미소장
12 Jimoh FO, Adedapo AA, Afolayan AJ, Comparison of the nutritional value and biological activities of the acetone, methanol and water extracts of the leaves of Solanum nigrum and Leonotis leonorus. Food Chem 2010; 48:964–971. 미소장
13 Kim K, Park M, Lee YM, MR Rhyu, Kim HY, Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation. Arch Pharm Res 2014; 37:1193–1200. 미소장
14 A human cellular model for studying the regulation of glucagon-like peptide-1 secretion. 네이버 미소장
15 Nitric Oxide: Cytotoxicity versus Cytoprotection— How, Why, When, and Where? 네이버 미소장
16 Simultaneous qualitative and quantitative analysis of phenolic acids and flavonoids for the quality control of Apocynum venetum L. leaves by HPLC-DAD-ESI-IT-TOF-MS and HPLC-DAD. 네이버 미소장
17 Glucagon-Like Peptide 1 Secretion by the L-Cell 네이버 미소장

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