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한국학술지인용색인(NRF)
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초록보기
Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) have been implicated in cancer development and progression. However, the effects of PAHs on carcinogenesis are still poorly understood. Here, we characterized a mouse cancer cell line BNL 1ME A. 7R.1 (1MEA) derived by transformation of non-tumorigenic liver cell line BNL CL.2 (BNL) using 3-methylcholanthrene (3MC), a carcinogenic PAH. RT-PCR and immunoblot analysis were used to determine the expression level of mRNA and proteins, respectively. To determine functionality, cell motility was assessed in vitro using a transwell migration assay. Both mRNA and protein levels of E-cadherin were significantly decreased in 1MEA cells in comparison with BNL cells. While the expression levels of mesenchymal markers and related transcription factors were enhanced in 1MEA cells, which could lead to increase in cell motility. Indeed, we found that 7-day exposure of BNL cells to 3-MC reduced the level of the adhesion molecule and epithelial marker E-cadherin and increased reciprocally the level of the mesenchymal marker vimentin in a dose-dependent manner. Taken together, these results indicate that the process of epithelial-mesenchymal transition (EMT) may be activated during premalignant transformation induced by 3-MC. A mechanism study to elucidate the relation between 3-MC exposure and EMT is underway in our laboratory.
권호기사
참고문헌 (27건) : 자료제공( 네이버학술정보 )
| 번호 | 참고문헌 | 국회도서관 소장유무 |
|---|---|---|
| 1 | A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects  |
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| 2 | Pelclová, D., Fenclová, Z., Dlasková, Z., Urban, P., Lukás, E., Procházka, B., Rappe, C., Preiss, J., Kocan, A. and Vejlupková, J. (2001) Biochemical, neuropsychological, and neurological abnormalities following 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD) exposure. Arch. Environ. Health, 56, 493-500. | 미소장 |
| 3 | Baccarelli, A., Mocarelli, P., Patterson, D.G. Jr., Bonzini, M., Pesatori, A.C., Caporaso, N. and Landi, M.T. (2002) Immunologic effects of dioxin: new results from Seveso and comparison with other studies. Environ. Health Perspect., 110, 1169-1173. | 미소장 |
| 4 | Short- and Long-Term Morbidity and Mortality in the Population Exposed to Dioxin after the "Seveso Accident" (Special Issue: Dioxins in Occupational and Environmental Health: Update) -- (Update of Classical Cases) |
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| 5 | Ligand binding and activation of the Ah receptor. |
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| 6 | Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. |
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| 7 | Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. |
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| 8 | Constitutive regulation of CYP1B1 by the aryl hydrocarbon receptor (AhR) in pre-malignant and malignant mammary tissue. |
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| 9 | The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. |
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| 10 | 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces matrix metalloproteinase (MMP) expression and invasion in A2058 melanoma cells. |
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| 11 | Contact inhibition and malignancy. |
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| 12 | Epithelial-mesenchymal transitions: twist in development and metastasis. |
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| 13 | The basics of epithelial-mesenchymal transition. |
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| 14 | Epithelial-Mesenchymal Transitions in Development and Disease |
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| 15 | Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. |
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| 16 | Biomarkers for epithelial-mesenchymal transitions. |
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| 17 | Activation of the dioxin/aryl hydrocarbon receptor (AhR) modulates cell plasticity through a JNK-dependent mechanism. |
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| 18 | Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity. |
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| 19 | Ikuta, T. and Kawajiri, K. (2006) Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor. Exp. Cell Res., 312, 3585-3594. | 미소장 |
| 20 | Harvey, R.G. (1982) Polycyclic hydrocarbons and cancer. Am. Sci., 70, 386-393. | 미소장 |
| 21 | Enzymatic oxidation of xenobiotic chemicals. |
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| 22 | Thiery, J.P. (2002) Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer, 2, 442-454. | 미소장 |
| 23 | Sanchez-Tilló, E., Liu, Y., de Barrios, O., Siles, L., Fanlo, L., Cuatrecasas, M., Darling, D.S., Dean, D.C., Castells, A. and Postigo, A. (2012) EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness. Cell. Mol. Life Sci., 69, 3429-3456. | 미소장 |
| 24 | Puisieux, A., Brabletz, T. and Caramel, J. (2014) Oncogenic roles of EMT-inducing transcription factors. Nat. Cell Biol., 16, 488-494. | 미소장 |
| 25 | Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells |
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| 26 | Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes |
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| 27 | Cancer therapy with antibodies and immunoconjugates. Proceedings of the 12th Conference on Cancer Therapy With Antibodies and Immunoconjugates. Parsippany, New Jersey, USA. October 16-18, 2008. |
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