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동의어 포함
In this study, we evaluated the lipoprotein lipase (LPL) inhibitory activity of 11 water extracts derived from Cinnamomum cassia Blume, Sarcodon aspratus, Cordyceps militaris, Crataegus pinnatifida Bunge, Corni fructus, Allium cepa, Coix lacryma-jobi, Plantago asiatica L., Lentinus edodes, Rosa rugosa, and Foeniculum fructus. The results of the LPL secretion and activity assay showed Sarcodon aspratus (NE) extract have an LPL secretion inhibitory acitivity. The cause of reduction in LPL secretion after NE treatment was investigated using molecular biology methods. NE treatment affected the LPL content in cells, but did not affect LPL mRNA expression. It also increased the mRNA expression level of sortilin-related receptor LDLR class A (SorLA), a receptor that induces endocytosis and intracellular trafficking of LPL.
Finally, cell fractionation revealed that NE treatment induced the expression of CCAAT-enhancer-binding protein beta (C/ EBPβ), a SorLA transcription factor, in the nuclei of 3T3-L1 adipocytes. These results show that NE’s anti-obesity effect involves inhibition of LPL secretion through C/EBPβ-mediated induction of SorLA expression.| 번호 | 참고문헌 | 국회도서관 소장유무 |
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| 39 | Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. ![]() |
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| 40 | SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. ![]() |
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| 41 | Differential Expression of LR11 during Proliferation and Differentiation of Cultured Neuroblastoma Cells ![]() |
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