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Streptococcus pneumoniae is a major human pathogen that is involved in community-acquired pneumonia. Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine that activates immune responses against infection, invasion, injury, or inflammation. To study the role of TNF-α during S. pneumoniae infection, a murine pneumococcal pneumonia model was used. We intranasally infected C57BL/6J wild-type (WT) and TNF-α knockout (KO) mice with S. pneumoniae D39 serotype 2. In TNF-α KO mice, continuous and distinct loss of body weight, and low survival rates were observed. Bacterial counts in the lungs and blood of TNF-α KO mice were significantly higher than those in WT mice.

Histopathological lesions in the spleen of TNF-α KO mice were more severe than those in WT mice. In TNF-α KO mice, severe depletion of white pulp was observed and the number of apoptotic cells was significantly increased. Interferon-gamma (IFN-γ), IL-12p70 and IL-10 levels in serum were significantly increased in TNF-α KO mice. TNF-α is clearly involved in the regulation of S. pneumoniae infections.

Early death and low survival rates of TNF-α KO mice were likely caused by a combination of impaired bacterial clearance and damage to the spleen. Our findings suggest that TNF-α plays a critical role in protecting the host from systemic S. pneumoniae infection.

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기사명 저자명 페이지 원문 목차
Spontaneous and transgenic rodent models of inflammatory bowel disease Susan Prattis, Abdo Jurjus pp.47-68
Prolonged oral administration of Gastrodia elata extract improves spatial learning and memory of scopolamine-treated rats 박영미, 이봉건, 박상훈, 오홍근, 강양규, 김옥진, 권이성, 김용필, 최민휴, 정용섭, 오지선, 이학용 pp.69-77
Tumor necrosis factor-alpha deficiency impairs host defense against Streptococcus pneumoniae 정동구, 서진희, 허승호, 최양규, 정의석 pp.78-85
Comparison of three diagnostic assays for the identification of Helicobacter spp. in laboratory dogs 홍선화, 정영호, 강원국, 최연식, 김옥진 pp.86-92
Expression of pancreatic and duodenal homeobox1(PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice 하시모토 하루오, 카미사코 츠토무, 카가와 타카히로, 하라구치 세이키, 야고토 미카, 타카하시 리이치, 카와이 켄지, 스에미즈 히로시 pp.93-98
<Erratum>In vitro and in vivo anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract Jingmei Cai, 김태수, 장자영, 김지현, 신경하, 이성표, 최은경, 김사현, 박민, 김종배, 김윤배 pp.99-99

참고문헌 (26건) : 자료제공( 네이버학술정보 )

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번호 참고문헌 국회도서관 소장유무
1 Protection against pneumococcal pneumonia in mice by monoclonal antibodies to pneumolysin. 네이버 미소장
2 O'Brien KL, Wolfson LJ, Watt JP, Henkle E, Deloria-Knoll M, McCall N, Lee E, Mulholland K, Levine OS, Cherian T; Hib and Pneumococcal Global Burden of Disease Study Team. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 2009; 374(9693): 893-902. 미소장
3 Tumor necrosis factor, other cytokines and disease. 네이버 미소장
4 TNF-R1 Signaling: A Beautiful Pathway 네이버 미소장
5 Early production of tumor necrosis factor‐α by Gr‐1+ cells and its role in the host defense to pneumococcal infection in lungs 네이버 미소장
6 Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice. 네이버 미소장
7 Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae. 네이버 미소장
8 Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. 네이버 미소장
9 Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection. 네이버 미소장
10 Fatal Sepsis in a Patient With Rheumatoid Arthritis Treated With Etanercept 네이버 미소장
11 Infections and anti-tumor necrosis factor alpha therapy. 네이버 미소장
12 Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis. 네이버 미소장
13 Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes. 네이버 미소장
14 Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa. 네이버 미소장
15 A pneumolysin-negative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. 네이버 미소장
16 Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia. 네이버 미소장
17 The Role Played by Tumor Necrosis Factor during Localized and Systemic Infection with Streptococcus pneumoniae 네이버 미소장
18 The innate immune response to pneumococcal lung infection: the untold story 네이버 미소장
19 Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. 네이버 미소장
20 Regulation of interferon-gamma during innate and adaptive immune responses. 네이버 미소장
21 IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. 네이버 미소장
22 IL-10: the master regulator of immunity to infection. 네이버 미소장
23 Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia. 네이버 미소장
24 IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages. 네이버 미소장
25 In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. 네이버 미소장
26 Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. 네이버 미소장

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